abstract：BACKROUND:A relatively small number of genetic variants are implicated to pathophysiology of intracerebral hemorrhage (ICH). Aquaporin-4 (AQP4) has been reported to be implicated in the pathophysiological processes of ICH development. OBJECTIVE:To examine the role of AQP4 gene region polymorphisms on the ICH risk. ME...

journal_title：Neuroscience letters

authors： Dardiotis E,Siokas V,Marogianni C,Aloizou AM,Sokratous M,Paterakis K,Dardioti M,Grigoriadis S,Brotis A,Kapsalaki E,Fountas K,Jagiella J,Hadjigeorgiou GM

更新日期：2019-03-23 00:00:00

abstract：:Eukaryotic mRNA precursors are co-transcriptionally assembled into ribonucleoprotein complexes. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in mRNA translocation, stability, subcellular localization and regulation of mRNA translation. About 20 major classes of hnRNPs have been identified in ...

journal_title：Neuroscience letters

authors： Lopes GS,Lico DTP,Silva-Rocha R,de Oliveira RR,Sebollela A,Paçó-Larson ML,Larson RE

更新日期：2019-03-23 00:00:00

abstract：:Transforming growth factor (TGF)-β stimulates release of interleukin (IL)-6, which is recognized to function as both a pro- and anti- inflammatory cytokine in the central nervous system, from astrocytes. It is generally recognized that effects of TGF-β are mediated through Smad-independent as well as Smad-dependent pa...

journal_title：Neuroscience letters

authors： Tanabe K,Kojima A,Tachi J,Nakashima D,Kozawa O,Iida H

更新日期：2019-03-23 00:00:00

abstract：:Uncoupling proteins (UCPs) belong to the mitochondrial anion carrier superfamily and catalyze important metabolic functions at the mitochondrial inner membrane. While the thermogenic role of UCP1 in brown fat of eutherian mammals is well established, the molecular functions of UCP1 in ectothermic vertebrates and of ot...

journal_title：Neuroscience letters

authors： Gaudry MJ,Jastroch M

更新日期：2019-03-23 00:00:00

abstract：:Hibernation in mammals is a whole-body phenotype that involves profound reductions in oxygen consumption, metabolic reactions, core body temperature, neural activity and heart rate. An important aspect of mammalian hibernation is the ability to reverse this state of hypothermic torpor by rewarming and subsequent arous...

journal_title：Neuroscience letters

authors： Oliver SR,Anderson KJ,Hunstiger MM,Andrews MT

更新日期：2019-03-23 00:00:00

abstract：:Essentially all animals with nervous systems utilize electrical synapses as a core element of communication. Electrical synapses, formed by gap junctions between neurons, provide rapid, bidirectional communication that accomplishes tasks distinct from and complementary to chemical synapses. These include coordination ...

journal_title：Neuroscience letters

authors： O'Brien J

更新日期：2019-03-16 00:00:00

abstract：:Pannexins form single membrane channels that regulate the passage of ions, small molecules and metabolites between the intra- and extracellular compartments. In the central nervous system, these channels are integrated into numerous signaling cascades that shape brain physiology and pathology. Post-translational modif...

journal_title：Neuroscience letters

authors： Lohman AW,Weilinger NL,Santos SM,Bialecki J,Werner AC,Anderson CL,Thompson RJ

更新日期：2019-03-16 00:00:00

abstract：:In membrane physiology, as in other fields, myths or speculations may be repeated so often and so widely that they are perceived as facts. To some extent, this has occurred with regard to gap junctions, hemichannels, pannexin channels and P2X7 (ionotropic receptors), especially concerning the interpretation of the ind...

journal_title：Neuroscience letters

authors： de Freitas PHM,da Silva Ferreira NC,Fioravante-Rezende JG,de Menezes Santos L,Alves LA,Rozental R

更新日期：2019-03-16 00:00:00

abstract：:Diffusion MRI studies characterizing the changes in white matter (WM) due to vascular cognitive impairment, which includes all forms of small vessel disease are reviewed. We reviewed the usefulness of diffusion methods in discriminating the affected WM regions and its relation to cognitive impairment. These studies we...

journal_title：Neuroscience letters

authors： Raja R,Rosenberg G,Caprihan A

更新日期：2019-02-16 00:00:00

abstract：:Emotions organize human and animal behaviour by automatically adjusting their actions at multiple physiological and behavioural scales. Recently, pattern recognition techniques have emerged as an important tool for quantifying the neural, physiological, and phenomenological organization of emotions in humans. Here we ...

journal_title：Neuroscience letters

authors： Nummenmaa L,Saarimäki H

更新日期：2019-02-06 00:00:00

abstract：:Converging evidence demonstrates an important role for gangliosides in brain function and neurodegenerative diseases. Exogenous GM1 is broadly neuroprotective, including in rodent, feline, and primate models of Parkinson's disease, and has shown positive effects in clinical trials. We and others have shown that inhibi...

journal_title：Neuroscience letters

authors： Dhanushkodi A,Xue Y,Roguski EE,Ding Y,Matta SG,Heck D,Fan GH,McDonald MP

更新日期：2019-01-23 00:00:00

abstract：:Sepsis-associated encephalopathy (SAE) has significant impact on the neurocognitive outcome of sepsis survivors. This study was conducted to analyze the amino-terminal propeptide of the C-type natriuretic peptide (NT-proCNP) as a biomarker for SAE in comparison to neuron-specific enolase (NSE) and S100B protein. Cereb...

journal_title：Neuroscience letters

authors： Ehler J,Saller T,Wittstock M,Rommer PS,Chappell D,Zwissler B,Grossmann A,Richter G,Reuter DA,Nöldge-Schomburg G,Sauer M

更新日期：2019-01-23 00:00:00

abstract：:The sigma-1 (σ1) receptor is a chaperone protein located on the mitochondria-associated membrane of the endoplasmic reticulum, while the sigma-2 receptor (σ2) is an endoplasmic reticulum-resident membrane protein. Recent evidence indicates that both of these receptors figure prominently in the pathophysiology of Alzhe...

journal_title：Neuroscience letters

authors： Jia H,Zhang Y,Huang Y

更新日期：2019-01-19 00:00:00

abstract：:In this review, we summarize the recent development of positron emission tomography (PET) radioligands for γ-aminobutyric acid A (GABAA) receptors and their potential to measure changes in endogenous GABA levels and highlight the clinical and translational applications of GABA-sensitive PET radioligands. We review the...

journal_title：Neuroscience letters

authors： Andersson JD,Matuskey D,Finnema SJ

更新日期：2019-01-19 00:00:00

abstract：:P2X receptors (P2XRs) are a family of ATP-gated ionic channels that are expressed in numerous excitable and non-excitable cells. Despite the great advance on the structure and function of these receptors in the last decades, there is still lack of specific and potent antagonists for P2XRs subtypes, especially for the ...

journal_title：Neuroscience letters

authors： Coddou C,Sandoval R,Hevia MJ,Stojilkovic SS

更新日期：2019-01-18 00:00:00

abstract：:Neural stem cells (NSCs) persist in the mammalian brain throughout life and protect against hypoxia-ischemia injury. NSCs are being increasingly recognized as a novel therapeutic target for various neurological disorders. Previous research indicates that miR-21 attenuates hypoxia-ischemia induced apoptotic death in va...

journal_title：Neuroscience letters

authors： Chen R,Tai Y,Zhang Y,Wang L,Yang Y,Yang N,Ma S,Xue F,Wang J

更新日期：2019-01-18 00:00:00

abstract：:Parkinson's disease (PD) is characterized by bradykinesia, resting tremor, rigidity and postural instability as well as early symptoms. Previous studies that evaluated the association between H1/H2 MAPT haplotype and PD were mostly conducted in European populations in which the H1 haplotype was a reported risk factor ...

journal_title：Neuroscience letters

authors： Miranda-Morales EG,Sandoval-Carrillo A,Castellanos-Juárez FX,Méndez-Hernández EM,La Llave-León O,Quiñones-Canales G,Ruano-Calderón LA,Arias-Carrión O,Salas-Pacheco JM

更新日期：2019-01-18 00:00:00

abstract：:The genetically heterozygous spinocerebellar ataxias are all characterized by cerebellar atrophy and pervasive Purkinje Cell degeneration. Up to date, more than 35 functionally diverse spinocerebellar ataxia genes have been identified. The main question that remains yet unsolved is why do some many genetic insults lea...

journal_title：Neuroscience letters

authors： Huang M,Verbeek DS

更新日期：2019-01-01 00:00:00

abstract：:The eyeblink conditioning paradigm captures an elementary form of associative learning in a neural circuitry that is understood to an extraordinary degree. Cerebellar cortical Purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (CRs), leading to disinhibition ...

journal_title：Neuroscience letters

authors： Ten Brinke MM,Boele HJ,De Zeeuw CI

更新日期：2019-01-01 00:00:00

abstract：:Canine degenerative myelopathy (DM) is an adult-onset progressive and fatal neurodegenerative disorder. Superoxide dismutase 1 (SOD1) mutations have been reported in affected dogs and immunohistochemical analyses revealed the accumulation of mutant SOD1 (E40K) in spinal neurons and astrocytes. Therefore, this disease ...

journal_title：Neuroscience letters

authors： Yokota S,Kobatake Y,Noda Y,Nakata K,Yamato O,Hara H,Sakai H,Nishida H,Maeda S,Kamishina H

更新日期：2018-11-20 00:00:00

abstract：:Autism spectrum disorder (ASD) is a group of developmental disorders characterized by social interaction deficits, communication impairments, and stereotyped and repetitive behaviors. Additionally, impairments in the GABAergic circuitry have been associated with ASD. Several studies have shown that dysfunction of the ...

journal_title：Neuroscience letters

authors： Varman DR,Soria-Ortíz MB,Martínez-Torres A,Reyes-Haro D

更新日期：2018-11-20 00:00:00

abstract：:The aims of the present work were to evaluate the exploratory activity in Sprague-Dawley rats, as well as to analyze the nigral and striatal mRNA expression of the plasticity-related genes bdnf and arc after L-buthionine sulfoximine (BSO) injection into substantia nigra compacta. Lesioned rats traveled less distance i...

journal_title：Neuroscience letters

authors： Díaz-Hung ML,Ruiz-Fuentes JL,Díaz-García A,León-Martínez R,Alberti-Amador E,Pavón-Fuentes N,Blanco-Lezcano L

更新日期：2018-11-20 00:00:00

abstract：:Thermogenetics is a promising innovative neurostimulation technique, which enables robust activation of single neurons using thermosensitive cation channels and IR stimulation. The main advantage of IR stimulation compared to conventional visible light optogenetics is the depth of penetration (up to millimeters). Due ...

journal_title：Neuroscience letters

authors： Roshchin M,Ermakova YG,Lanin AA,Chebotarev AS,Kelmanson IV,Balaban PM,Zheltikov AM,Belousov VV,Nikitin ES

更新日期：2018-11-20 00:00:00

abstract：:In this study, we investigated the eye movement and postural control performance in dyslexic children while reading text and performing Landolt reading when sitting and standing. Fifteen dyslexic and 15 non-dyslexic children were asked to sit in a chair while the eye movements were recorded, and were then asked to sta...

journal_title：Neuroscience letters

authors： Razuk M,Barela JA,Peyre H,Gerard CL,Bucci MP

更新日期：2018-11-01 00:00:00

abstract：:Alcohol abuse and anxiety disorders often occur concurrently, but their underlying cellular mechanisms remain unclear. N-methyl-D-aspartic acid receptors (NMDARs) have recently received attention from those interested in the neurobiology of anxiety. A chronic alcohol exposure rat model (28 consecutive days of 20% alco...

journal_title：Neuroscience letters

authors： Yuanyuan J,Junyan Z,Cuola D,Jingjing C,Yuhui S,Dan X,Wei D,Yongsheng Z

更新日期：2018-11-01 00:00:00

abstract：:Intellectual disability (ID) is one of the most prevalent chronic developmental brain disorders or phenotype of syndromic ID, affecting nearly 1-2% of the general population worldwide. Over recent decades, tremendous effort and high-throughput platforms have been devised to explore the complex heterogeneity, numerous ...

journal_title：Neuroscience letters

authors： Chen C,Chen D,Xue H,Liu X,Zhang T,Tang S,Li W,Xu X

更新日期：2018-10-15 00:00:00

abstract：:Acetaldehyde (AcH) and salsolinol play important roles in the central effects of ethanol. This study aimed to investigate the effect of administration of AcH on dopamine (DA), DA-derived salsolinol and serotonin (5-HT) levels in the dorsal striatum of Aldh2-knockout (Aldh2-KO) and C57BL/6 N (WT) mice. Animals were tre...

journal_title：Neuroscience letters

authors： Ito A,Jamal M,Ameno K,Tanaka N,Takakura A,Kawamoto T,Kitagawa K,Nakayama K,Matsumoto A,Miki T,Kinoshita H

更新日期：2018-10-15 00:00:00

abstract：:In the injured brain, astrocytes become activated and increase GFAP expression; a phenomenon termed as astrogliosis. Previously, we have reported that DJ-1, a Parkinson's disease gene, positively regulates astrogliosis in the injured brain. Moreover, STAT3 is known to play a key role in the regulation of astrogliosis....

journal_title：Neuroscience letters

authors： Choi DJ,Kwon JK,Joe EH

更新日期：2018-10-15 00:00:00

abstract：:Emotion regulation difficulties have been involved in multiple forms of psychopathology and may represent an important focus for current efforts to understand the biological mechanisms underlying transdiagnostic symptoms. The present study investigated a gene-environment interaction (G × E) in reappraisal, a form of e...

journal_title：Neuroscience letters

authors： Bîlc MI,Vulturar R,Chiș A,Buciuman M,Nuţu D,Bunea I,Szentágotai-Tătar A,Miu AC

更新日期：2018-10-15 00:00:00

abstract：:Neurodegenerative disorders such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by impairment of autophagy. Cellular survival is dependent on efficient clearance of phosphorylated α-synuclein, which accumulates as fibrils in the neuronal cytoplasm as Lewy bodies (LBs). The forkhead b...

journal_title：Neuroscience letters

authors： Miki Y,Tanji K,Mori F,Utsumi J,Sasaki H,Kakita A,Takahashi H,Wakabayashi K

更新日期：2018-09-25 00:00:00

abstract：:To investigate the effect of bilateral low-frequency repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor (BDNF) and serotonin (5-HT) in patients with generalized anxiety disorders (GAD). As compared with before treatment, the HARS score in p...

journal_title：Neuroscience letters

authors： Lu R,Zhang C,Liu Y,Wang L,Chen X,Zhou X

更新日期：2018-09-25 00:00:00

abstract：:Global cerebral ischemia-reperfusion (GCI/R) may occur after any of several clinical conditions such as cardiac arrest and anesthetic accident. Some dopamine receptor agonists possess neuroprotective effects. However, some of them may produce side effects during treatment. Piribedil, which is a dopamine D2/D3 receptor...

journal_title：Neuroscience letters

authors： Wang W,Liu L,Chen C,Jiang P,Zhang T

更新日期：2018-09-25 00:00:00

abstract：:The central nervous system preplans postural responses to successfully perform complex multi-joint movements. These responses have been termed anticipatory postural adjustments (APAs), and they constitute a general type of response to stabilize posture prior to movement initiation. APA sequences are elicited with shor...

journal_title：Neuroscience letters

authors： Kennefick M,Wright AD,Smirl JD,van Donkelaar P

更新日期：2018-09-25 00:00:00

abstract：:Consummatory successive negative contrast (cSNC) occurs when animals exposed to an unexpected downshift from a high palatable reward (e.g., 32% sucrose solution) to a less preferred one (e.g., 4% sucrose solution) show an abrupt and transient suppression of the consummatory response, compared with control animals that...

journal_title：Neuroscience letters

authors： Annicchiarico I,Cuenya L

更新日期：2018-09-25 00:00:00

abstract：:Emotions are at the core of human cognition and behavior. Traditionally, emotions have been classified dichotomously as being either positive or negative. However, recent behavioral research (An et al., 2017) suggests that emotions contain both positivity and negativity. The current work investigated neural correlates...

journal_title：Neuroscience letters

authors： An S,Han X,Wu B,Shi Z,Marks M,Wang S,Wu X,Han S

更新日期：2018-09-25 00:00:00

abstract：:Assessments of the pharmacological profiles of antipsychotic agents have shown that the serotonin receptor family is often involved in their pharmacodynamics. Response to antipsychotic therapy is highly variable, yet prognostic biomarkers are lacking. The aim of the study was to investigate the association of 14 singl...

journal_title：Neuroscience letters

authors： Zhou W,Chang W,Yan Y,Shen L,Li W,Yi Z,Qin S

更新日期：2018-09-14 00:00:00

abstract：:Mere observation of objects in our surroundings can potentiate movement, a fact reflected by visually-primed activation of motor cortical networks. This mechanism holds potential value for reactive balance control where recovery actions of the arms or legs must be targeted to a new support base to avoid a fall. The pr...

journal_title：Neuroscience letters

authors： McDannald DW,Mansour M,Rydalch G,Bolton DAE

更新日期：2018-09-14 00:00:00

abstract：:Depression associated with diabetes has been described as a highly debilitating comorbidity. Due to its complex and multifactorial mechanisms, the treatment of depression associated with diabetes represents a clinical challenge. Cannabidiol (CBD), the non-psychotomimetic compound derived from Cannabis sativa, has been...

journal_title：Neuroscience letters

authors： de Morais H,Chaves YC,Waltrick APF,Jesus CHA,Genaro K,Crippa JA,da Cunha JM,Zanoveli JM

更新日期：2018-08-24 00:00:00

abstract：:The pathophysiology of Parkinson's disease exhibit imperative roles in unfolded protein response stress-induced oxidative stress and inflammation in general. Although, delta opioid receptor (DOR), has been found to represent anti-parkinsonian effect at behavioral level, its underlying mechanism remains elusive till da...

journal_title：Neuroscience letters

authors： Begum M ET,Sen D

更新日期：2018-06-21 00:00:00

abstract：:Long-term potentiation (LTP) in the dentate gyrus was previously shown to be enhanced by nicotine, an effect dependent on both homomeric α7 and heteromeric α2β2 nicotinic acetylcholine receptors (nAChR). In our experiments, bath-applied nicotine produced no significant enhancement of LTP. The α7 nAChR silent agonist N...

journal_title：Neuroscience letters

authors： Papke RL,Peng C,Kumar A,Stokes C

更新日期：2018-06-11 00:00:00